METBLUE Methylene Blue Reagent. CI 52015 PhEur solution 1% highest quality 100ml

Methylene blue (MB) may have a positive effect on brain function and support the treatment of some neurological disorders. Its ability to improve memory and creativity is due to its neuroprotective properties and the ability to increase energy production at the cellular level in the mitochondria. By improving the efficiency of mitochondrial processes, MB supports cognitive functions such as working memory and learning abilities. In addition, MB acts as a strong antioxidant that protects neurons against oxidative stress, which is important in the prevention and treatment of neurodegenerative disorders such as Alzheimer's disease , Parkinson's or Huntington's disease. Methylene blue also has a modulating effect on neurotransmitters such as serotonin, dopamine and norepinephrine, which affects to improve mood and motivational and creative functions, and may also help in the treatment of depressive disorders. Studies have shown that MB may have a beneficial effect in the treatment of neurodegenerative diseases, delaying the progression of symptoms such as loss of memory and motor functions.

Methylene blue (MB) acts as a strong antioxidant, which means that it neutralizes harmful free radicals that are produced in the body during metabolic processes. Free radicals can lead to cell damage, which contributes to the development of diseases, including neurodegenerative diseases, cancer and accelerated aging of the body.

The antioxidant effect of MB consists in supporting mitochondria, i.e. cellular "power plants", in the energy production process, while protecting cells against oxidative stress. Thanks to this, cells are less susceptible to damage and can function properly for longer.

Thanks to these properties, MB is used in research on the prevention and treatment of neurodegenerative diseases such as Alzheimer's or Parkinson's, where oxidative stress plays an important role in the progression of the disease.

Methylene blue (MB) is an effective drug used to treat methemoglobinemia, a condition in which hemoglobin (the oxygen-transporting protein in red blood cells) is converted to methemoglobin, which is unable to transport oxygen. As a result, tissue hypoxia occurs, which may lead to serious health problems.

Mechanism of Action

1. Methemoglobin Reduction: Methemoglobin acts as a reducer, restoring methemoglobin to the active form of hemoglobin. It works by donating electrons, which results in the conversion of methemoglobin back to a form that is capable of transporting oxygen.
2. Fast Action: MB acts quickly, making it effective in emergency situations where it is necessary to immediately restore the oxygen transport capacity of hemoglobin.

Methylene blue (MB) is used in medicine as an effective agent in the treatment of various infections. Its action is due to its antibacterial and antiseptic properties, which makes it useful in the treatment of:

1. Urinary tract infections: Methylene blue is often used to treat urinary tract infections, helping to eliminate bacteria and relieve symptoms associated with the infection.
2. Sexually transmitted infections: It is also used to treat some sexually transmitted infections, where its coloring properties help in diagnosis and effectively fight pathogens.
3. Mechanism of action: MB works by interacting with the nucleic acids of bacteria, interfering with their metabolism and multiplication, leading to their elimination. In addition to its antibacterial effect, methylene blue can also promote wound healing thanks to its antiseptic properties.

Methylene blue (MB) is a substance that has great potential in the treatment of malaria, especially in the context of increasingly common drug resistance among the pathogens causing this disease.

1. Mechanism of action: MB works in various ways, including by interacting with enzymes and cellular proteins of malaria parasites, which can lead to their death. Its antimalarial effect may be due to its ability to disrupt biochemical processes in the parasite's cells.
2. Therapeutic potential: Studies show that methylene blue can be used as an adjunct to standard malaria therapies, especially in cases of resistance to other drugs [ 1 ]. Additionally, MB can be used in combination with other substances to increase its effectiveness.
3. Clinical trials: Many clinical trials are examining the use of MB in malaria therapy, and initial results are promising. Although MB will not replace the main drugs used to treat malaria, it may represent a valuable alternative or complement to therapeutic strategies.

In conclusion, methylene blue has potential in the treatment of malaria and may be a promising option, especially in the face of increasing resistance to conventional therapies.

Detoxification after cyanide poisoning using methylene blue (MB) is a promising therapeutic approach that takes advantage of the properties of this compound in the fight against cyanide toxicity.

1. Mechanism of action of MB: Methylene blue acts as a reducing agent, which means it can help restore mitochondrial function in cells that are inhibited by cyanide. Cyanide acts on enzymes in the mitochondria, blocking the use of oxygen and leading to cell death. MB can therefore reduce the effects of this blocking by supporting cellular respiration.
2. Clinical Use: In clinical trials, MB has been studied as a potential antidote for cyanide poisoning, particularly in emergency situations. Its use may be considered as an adjunct to traditional detoxification methods, which include medications such as sodium thiosulfate and amyl nitrite.
3. Benefits: The use of MB for detoxification may lead to faster resolution of poisoning symptoms such as headache, weakness and dizziness that appear as a result of the effects of cyanide.

Methylene blue (MB) is gaining attention as a potential antiviral agent, including in the context of COVID-19. Its action relies on several mechanisms that can support the fight against viruses:

1. Mechanism of action of MB: Methylene blue acts as a reducing agent, which affects the redox balance in cells. It may support antioxidant processes by reducing oxidative damage caused by viruses. Moreover, MB can influence mitochondrial function, which is crucial in the body's immune response.
2. Effects on the SARS-CoV-2 virus: Laboratory studies suggest that MB may affect the SARS-CoV-2 virus, inhibiting its replication. This is particularly important in the context of COVID-19, where blocking virus replication may help limit the development of the disease.
3. Clinical studies: Preliminary studies have shown that the use of MB may reduce the severity of COVID-19 symptoms, and its antiviral effects may be beneficial in therapies supporting the treatment of infections.
4. Safe use: MB is generally considered safe to use at low doses, making it an interesting candidate for further research into its effectiveness in the context of viruses including SARS-CoV-2 [2].

Methylene blue (MB) has the potential to support mitochondrial metabolism through several mechanisms. Mitochondria are crucial for the production of cellular energy in the form of ATP and also play a role in regulating metabolic pathways and stress responses. MB may support these functions thanks to its redox and antioxidant properties:

1. Reduction of oxidative stress: MB acts as an antioxidant, helping to neutralize free radicals and protect mitochondria from oxidative damage that can lead to energy imbalances and cell damage.
2. Support in ATP production: Due to MB's ability to reduce and improve redox balance, it can support the efficiency of ATP production in mitochondria, which is crucial for maintaining cellular functions.
3. Improved Mitochondrial Performance: Methylene blue may support mitochondrial function, which translates into better energy utilization by cells and improved metabolic health.

Methylene blue (MB) is known for its potential to support cell regeneration, primarily through several key biochemical mechanisms:

1. Improved mitochondrial function: MB acts as an electron carrier in the mitochondrial respiratory chain, supporting ATP production. ATP is necessary for the proper functioning of cells, including regeneration, because it provides the energy needed to repair damaged cellular structures and carry out biosynthetic processes.
2. Antioxidant: Methylene blue has antioxidant properties that help neutralize free radicals. Oxidative damage is one of the main causes of cell aging and disease damage. MB reduces this damage by improving the cells' ability to regenerate.
3. Stimulation of repair processes: MB has properties that support DNA repair processes. As a result of its action, the effectiveness of repairing genetic damage increases, which accelerates tissue regeneration, especially in the case of damage caused by oxidative stress.
4. Modulation of the immune response: MB can influence the body's immune response, supporting repair processes in damaged tissues, as well as stimulating the production of cytokinins, which play a key role in tissue regeneration.

Thanks to these properties, methylene blue is a promising agent supporting cell regeneration, both in the context of treating oxidative damage and supporting repair processes in organisms.

Methylene blue (MB) has anti-inflammatory properties, which are the result of its action on a number of biological mechanisms in the body:

1. Reduction of oxidative stress: MB acts as a strong antioxidant, neutralizing free radicals, which are the main causes of inflammation. By reducing reactive oxygen species (ROS), MB reduces cell and tissue damage, which helps reduce inflammation in the body.
2. Modulation of the immune response: MB affects the immune system by modulating the inflammatory response by regulating the activity of inflammatory cells such as macrophages and lymphocytes. As a result, it may help control the excessive inflammatory response that leads to autoimmune diseases and other inflammatory conditions.
3. Effect on pro-inflammatory cytokines: Methylene blue may reduce the level of pro-inflammatory cytokines, such as TNF-α, IL-6 and IL-1β, which are responsible for the development of inflammation. Reducing their production helps alleviate inflammatory symptoms and prevents chronic inflammation.
4. Support for mitochondrial functions: MB also affects mitochondria, which play a key role in generating cellular energy and regulating inflammatory responses. Supporting their function can reduce inflammation, especially in immune cells such as macrophages.

Methylene blue (MB) may improve blood flow through several mechanisms that affect the functioning of the circulatory system:

1. Vasodilation: MB has an effect that may affect the relaxation of smooth muscles in blood vessels. This causes them to expand, which can improve blood flow and increase the supply of oxygen and nutrients to the tissues, as well as improve the removal of metabolic products.
2. Increasing nitric oxide (NO) levels: MB affects the body's nitric oxide levels, which are crucial for regulating blood pressure and vasodilation. Nitric oxide acts as a natural vasodilator, which leads to lower vascular resistance and improved blood flow.
3. Improved microcirculation: Research suggests that MB may influence microcirculation, which is particularly important in the context of improving blood supply in smaller blood vessels. Increasing blood flow in microcirculation supports regenerative processes in tissues and organs.
4. Supporting mitochondrial function: Methylene blue supports the function of mitochondria, which are responsible for the production of cellular energy. Better mitochondrial function can improve cellular metabolism and therefore support better blood flow, especially in tissues with high oxygen demand.

Methylene blue (MB) has potential to support the treatment of chronic pain through several mechanisms of action, including effects on the nervous system and through its anti-inflammatory and antioxidant properties:

1. Anti-inflammatory effects: Chronic pain is often the result of inflammation in the body. MB has the ability to reduce inflammation, which may contribute to pain reduction, especially in cases where pain is associated with inflammation.
2. Neuroprotective properties: MB influences mitochondrial metabolism and redox balance in cells, which may support the health of the nervous system. For this reason, it may help relieve neuropathic pain, which is the result of nerve damage or malfunction.
3. Ability to modulate inflammatory responses in the nervous system: MB may have a modulatory effect at the level of the nervous system, which allows for the regulation of pain sensitivity, especially in cases of neuropathic pain and pain resulting from chronic inflammation.
4. Application in cancer pain: Research on methylene blue suggests that it may support the treatment of cancer pain, acting both as an analgesic and by supporting cell regeneration processes, which is crucial in the treatment of chronic cancer-related pain.